M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (beta5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells[1][2].
Molecular Weight:
329.16
Purity:
98
CAS Number:
[2285330-15-4]
Formula:
C17H20BNO5
Target:
Apoptosis,Proteasome
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
