IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 µM, 0.072 µM and 1.38 µM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 µM[1].
Molecular Weight:
436.48
Purity:
99.96
CAS Number:
[1429179-07-6]
Formula:
C23H25FN6O2
Target:
Isocitrate Dehydrogenase (IDH)
Application Notes:
MCE Product type: Reference compound
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