MA242 is a specific dual inhibitor of MDM2 and NFAT1. MA242 directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 induces apoptosis in pancreatic cancer cell lines regardless of p53 status[1].
Molecular Weight:
579.98
Purity:
99.37
CAS Number:
[1049704-18-8]
Formula:
C26H21ClF3N3O5S
Target:
Apoptosis,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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