MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations IC50 value of 1.5 nM in inhibition of growth of RS4,11 cells. MD-224 has the potential to be a new class of anticancer agent[1]. MD-224 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molecular Weight:
889.80
Purity:
99.60
CAS Number:
[2136247-12-4]
Formula:
C48H43Cl2FN6O6
Target:
E1/E2/E3 Enzyme,MDM-2/p53,PROTACs
Application Notes:
MCE Product type: Reference compound
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