GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimers disease and amyotrophic lateral sclerosis (ALS)[1].
Molecular Weight:
419.44
Purity:
99.53
CAS Number:
[1620573-48-9]
Formula:
C21H24F3N5O
Target:
JNK,MAP3K
Application Notes:
MCE Product type: Reference compound
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