DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo[1].
Molecular Weight:
735.80
Purity:
99.92
CAS Number:
[1855860-24-0]
Formula:
C41H42FN5O7
Target:
c-Met/HGFR,TAM Receptor,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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