TNF-alpha-IN-19 is an inhibitor of TNFalpha that can block the interaction between TNFalphaRI, TRADD, and RIP1, the EC50 values for TNFalpha, IL-1beta, and IL-1beta/TNFalpha are 2.451, 3.792 and 1.54 µM, respectively. TNF-alpha-IN-19 only inhibits the degradation of IkappaBalpha when cells are stimulated by TNFalpha and not by IL-1beta[1].
Molecular Weight:
348.71
CAS Number:
[338773-13-0]
Formula:
C16H8ClF3N4
Target:
IKK,Interleukin Related,RIP kinase,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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