Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4,11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
Molecular Weight:
351.83
Purity:
98.85
CAS Number:
[2435715-90-3]
Formula:
C17H22ClN3O3
Target:
E3 Ligase Ligand-Linker Conjugates
Application Notes:
MCE Product type: Reference compound
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