GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK[1][2].
Molecular Weight:
400.21
Purity:
98
CAS Number:
[1644443-92-4]
Formula:
C20H11Cl2NO4
Target:
Autophagy,Kinesin,ULK
Application Notes:
MCE Product type: Reference compound
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