TASIN-1 (hydrochloride), CAS [[1678515-13-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-116572
Supplier Catalog Number:
HY-116572
Alternative Catalog Number:
MCE-HY-116572-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
TASIN-1 hydrochloride is a selective inhibitor of truncated APCTR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 hydrochloride specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 hydrochloride exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 hydrochloride can be used to prevent and intervene in APC mutant colorectal cancer[1][2][3].
Molecular Weight:
388.95
CAS Number:
[1678515-13-3]
Formula:
C18H29ClN2O3S
Target:
Apoptosis,Caspase,JNK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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