KRCA-0377 is an orally active ALK inhibitor with an IC50 of 0.001 µM. KRCA-0377 also inhibits mutant ALK enzyme with IC50 values 0.01 µM. KRCA-0377 shows cytotoxicity against cancer cells and inhibits tumor growth in xenograft mice models. KRCA-0377 can be used for the research of ALK-positive non-small-cell lung cancer[1].
Molecular Weight:
488.00
CAS Number:
[1845711-03-6]
Formula:
C23H26ClN5O3S
Target:
Anaplastic lymphoma kinase (ALK)
Application Notes:
MCE Product type: Reference compound
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