PIN1 inhibitor API-1, CAS [[680622-70-2]]

Product Overview

• Article Name: PIN1 inhibitor API-1, CAS [[680622-70-2]]
• Biozol Catalog Number: MCE-HY-116716
• Supplier Catalog Number: HY-116716
• Alternative Catalog Number: MCE-HY-116716-10MG,MCE-HY-116716-25MG,MCE-HY-116716-100MG,MCE-HY-116716-50MG,MCE-HY-116716-5MG,MCE-HY-116716-10MMX1ML
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1].

Product Properties

• Molecular Weight: 366.30
• Purity: 99.63
• CAS Number: [680622-70-2]
• Formula: C15H13F3N6O2
• Target: MicroRNA

Application Notes

• Application Notes: MCE Product type: Reference compound