Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3beta and CDK-5 with IC50s of 10.2 µM and 1.5 µM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4].
Molecular Weight:
548.76
Purity:
98.2
CAS Number:
[104196-68-1]
Formula:
C36H44N4O
Target:
Autophagy,CDK,GSK-3,HSV,Parasite,Proton Pump
Application Notes:
MCE Product type: Natural Products
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