TP0427736 (hydrochloride), CAS [[2459963-17-6]]

Product Overview

• Article Name: TP0427736 (hydrochloride), CAS [[2459963-17-6]]
• Biozol Catalog Number: MCE-HY-118528A
• Supplier Catalog Number: HY-118528A
• Alternative Catalog Number: MCE-HY-118528A-5MG,MCE-HY-118528A-50MG,MCE-HY-118528A-10MG,MCE-HY-118528A-25MG,MCE-HY-118528A-100MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-beta1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].

Product Properties

• Molecular Weight: 334.85
• Purity: 99.22
• CAS Number: [2459963-17-6]
• Formula: C14H11ClN4S2
• Target: TGF-beta Receptor

Application Notes

• Application Notes: Reference compound