VU041 is a first submicromolar-affinity inhibitor of Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC50 values of 2.5 µM and 1.7 µM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC50 of 12.7 µM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function[1].
Molecular Weight:
363.38
Purity:
99.31
CAS Number:
[332943-64-3]
Formula:
C19H20F3N3O
Target:
Parasite,Potassium Channel
Application Notes:
MCE Product type: Reference compound1
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