Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin-1 is a potent and selective PIKfyve inhibitor and inhibits late-stage autophagy by impairing lysosomal maturation. Vacuolin-1 can induce vacuole formation and increase the percentage of enucleated cells[1][2][4].
Molecular Weight:
577.42
Purity:
98.54
CAS Number:
[351986-85-1]
Formula:
C26H24IN7O
Target:
Autophagy,PIKfyve
Application Notes:
MCE Product type: Reference compound
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