NS-6740 is a partial agonist of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) with an IC50 of 3 nM. NS-6740 also acts as a potent modulator of the cholinergic anti-inflammatory pathway. NS-6740 alters the signaling pattern of alpha7 in an ion channel-independent manner, thereby reducing synaptic function. NS-6740 induces the desensitized state of alpha7 nAChR. NS-6740 generates robust nAChR-mediated currents. NS-6740 reduces LPS (HY-D1056)-induced TNF-alpha release from microglia. NS-6740 can be used in the research of neuroinflammation and neuropathic pain[1][2].
Molecular Weight:
364.36
CAS Number:
[753500-02-6]
Formula:
C19H19F3N2O2
Target:
nAChR,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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