AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC50=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors[1].
Molecular Weight:
599.96
CAS Number:
[1448346-43-7]
Formula:
C29H22ClF4N5O3
Target:
Isocitrate Dehydrogenase (IDH)
Application Notes:
MCE Product type: Reference compound1
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