AM-6226 is a potent and orally active G protein coupled receptor 40 (GPR40) full agonist with an EC50 of 0.12 µM. AM-6226 can activate the GPR40 receptors on pancreatic beta cells and enteroendocrine L cells, promote insulin secretion in a glucose-dependent manner and also increase the release of incretin hormones (GLP-1, GIP), thereby avoiding the risk of hypoglycemia. AM-6226 can be used for the research of metabolic disease, such as diabetes[1].
Molecular Weight:
522.62
CAS Number:
[1449742-87-3]
Formula:
C32H36F2O4
Target:
Free Fatty Acid Receptor
Application Notes:
MCE Product type: Reference compound
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