NCDM-32B is a potent and selective KDM4 inhibitor, with IC50 values of 3.0 µM for KDM4A and 1.0 µM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer[1][2].
Molecular Weight:
302.41
Purity:
97
CAS Number:
[1239468-48-4]
Formula:
C15H30N2O4
Target:
Histone Demethylase
Application Notes:
MCE Product type: Reference compound
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