BRD1172 (ML320) is a selectivity GSK3beta inhibitor with an IC50 of 24 nM for GSK3beta over CDK5. BRD1172 significantly inhibits GSK3beta-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3beta on beta-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimers disease, cardiac hypertrophy and cancers research[1].
Molecular Weight:
391.39
CAS Number:
[1597438-86-2]
Formula:
C20H20F3N3O2
Target:
GSK-3,beta-catenin
Application Notes:
MCE Product type: Reference compound1
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