(R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is a selective and orally effective inhibitor of MMP-12 with IC50 values for human, mouse and rat MMP-12 of 2 nM, 160 nM and 3 µM respectively. MMP408 exhibits IC50 value for human MMP-13 of 120 nM, and its activity against other MMPs is weak. MMP408 can alleviate inflammation, fibrosis and tissue remodeling by inhibiting MMP-12. MMP408 can be used in the research of chronic obstructive pulmonary disease and chronic sinusitis with nasal polyps.
Molecular Weight:
420.44
Purity:
99.91
CAS Number:
[1258003-93-8]
Formula:
C19H20N2O7S
Target:
Drug Isomer,MMP
Application Notes:
MCE Product type: Reference compound
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