Lorlatinib, CAS [[1454846-35-5]]

Product Overview

• Article Name: Lorlatinib, CAS [[1454846-35-5]]
• Biozol Catalog Number: MCE-HY-12215
• Supplier Catalog Number: HY-12215
• Alternative Catalog Number: MCE-HY-12215-50MG,MCE-HY-12215-25MG,MCE-HY-12215-10MMX1ML,MCE-HY-12215-5MG,MCE-HY-12215-100MG,MCE-HY-12215-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: PF-06463922

Product Description

Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of L1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively[1][2][3].

Product Properties

• Molecular Weight: 406.41
• Purity: 99.99
• CAS Number: [1454846-35-5]
• Formula: C21H19FN6O2
• Target: Anaplastic lymphoma kinase (ALK),Apoptosis,ROS Kinase

Application Notes

• Application Notes: MCE Product type: Reference compound