IWR-1, CAS [[1127442-82-3]]

Product Overview

• Article Name: IWR-1, CAS [[1127442-82-3]]
• Biozol Catalog Number: MCE-HY-12238
• Supplier Catalog Number: HY-12238
• Alternative Catalog Number: MCE-HY-12238-100MG,MCE-HY-12238-5MG,MCE-HY-12238-50MG,MCE-HY-12238-10MMX1ML,MCE-HY-12238-25MG,MCE-HY-12238-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: endo-IWR 1, IWR-1-endo

Product Description

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/beta-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of beta-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/beta-catenin downstream targets. IWR-1 promotes beta-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis[1][2][4].

Product Properties

• Molecular Weight: 409.44
• Purity: 99.60
• CAS Number: [1127442-82-3]
• Formula: C25H19N3O3
• Target: Organoid,Wnt

Application Notes

• Application Notes: MCE Product type: Reference compound