IWR-1 (GMP), CAS [[1127442-82-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-12238G
Supplier Catalog Number:
HY-12238G
Alternative Catalog Number:
MCE-HY-12238G-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
endo-IWR 1 (GMP), IWR-1-endo (GMP)
IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/beta-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of beta-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/beta-catenin downstream targets. IWR-1 promotes beta-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis[1][2][4].
Molecular Weight:
409.44
CAS Number:
[1127442-82-3]
Formula:
C25H19N3O3
Target:
Organoid,Wnt
Application Notes:
MCE Product type: GMP Small Molecules
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