TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib (HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984)[1].
Molecular Weight:
1002.57
Purity:
98.01
CAS Number:
[2229037-19-6]
Formula:
C49H60ClN9O10S
Target:
Anaplastic lymphoma kinase (ALK),PROTACs
Application Notes:
Reference compound
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