HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1). HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis[1][2].
Molecular Weight:
360.36
Purity:
98.90
CAS Number:
[1186371-31-2]
Formula:
C21H16N2O4
Target:
Apoptosis,Cyclophilin,LPL Receptor,MDM-2/p53,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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