LMP-420 is a selective tumor necrosis factor-alpha (TNF-alpha) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1beta, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection[1].
Molecular Weight:
283.52
CAS Number:
[473870-63-2]
Formula:
C10H15BClN5O2
Target:
Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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