hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kalpha/gamma (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 µM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].
Molecular Weight:
566.07
Purity:
99.82
CAS Number:
[1402452-15-6]
Formula:
C27H28ClN7O3S
Target:
CDK,GSK-3,mTOR,PI3K
Application Notes:
MCE Product type: Reference compound1
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