delta-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific delta-secretase inhibitor, with an IC50 of 0.7 µM. delta-Secretase inhibitor 11 interacts with both the active site and allosteric site of delta-secretase. delta-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. delta-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. delta-Secretase inhibitor 11 can be used for Alzheimers disease research[1].
Molecular Weight:
220.23
Purity:
99.89
CAS Number:
[842964-18-5]
Formula:
C10H12N4O2
Target:
Amyloid-beta,Caspase
Application Notes:
Reference compound
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