PolyQ aggregation inhibitor C2-8, CAS [[300670-16-0]] Preis auf Anfrage

Product Overview

• Article Name: PolyQ aggregation inhibitor C2-8, CAS [[300670-16-0]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-125172
• Supplier Catalog Number: HY-125172
• Alternative Catalog Number: MCE-HY-125172-5MG,MCE-HY-125172-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Polyglutamine Aggregation inhibitor III

Product Description

C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 µM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntingtons disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntingtons disease.

Product Properties

• Molecular Weight: 510.20
• Purity: 99.9
• CAS Number: [300670-16-0]
• Formula: C19H14Br2N2O3S
• Target: Huntingtin

Application Notes

• Application Notes: MCE Product type: Reference compound