Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects[1][2].
Molecular Weight:
458.57
Purity:
99.77
CAS Number:
[68844-77-9]
Formula:
C28H31FN4O
Target:
Histamine Receptor,Potassium Channel
Application Notes:
MCE Product type: Reference compound1
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