Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC50 value of 20.7 µM and a potent inhibitor of clathrin-mediated endocytosis with an IC50 value of 6.9 µM. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line[1][2][3][4][5].
Molecular Weight:
426.15
Purity:
99.87
CAS Number:
[253449-04-6]
Formula:
C17H18Br2N2O
Target:
Arp2/3 Complex
Application Notes:
MCE Product type: Reference compound
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