TH251 is a LIMK1 and LIMK2 inhibitor with IC50s of 52 nM and 47 nM against LIMK1 and LIMK2, respectively. TH251 binds to inactive alphaC-out and DFG-out LIMK1 conformations, inhibits unphosphorylated LIMK1 and LIMK2 enzymatic activity, and exhibits unchanged potency despite PAK-mediated phosphorylation of either kinase. TH251 can be used for the research of cancers, glaucoma, and CNS diseases[1][2].
Molecular Weight:
394.49
CAS Number:
[1622059-04-4]
Formula:
C22H22N2O3S
Target:
LIM Kinase (LIMK)
Application Notes:
MCE Product type: Reference compound
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