Pittsburgh Compound B (PiB) is a PET tracer for Abeta deposition in Alzheimers disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Abeta complexes. Pittsburgh Compound B holds great potential in Alzheimers disease research[1].
Molecular Weight:
256.33
Purity:
98
CAS Number:
[566169-93-5]
Formula:
C14H12N2OS
Target:
Amyloid-beta
Application Notes:
MCE Product type: Reference compound
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