Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Abeta deposition PET tracer that binds to Abeta(1-40) fibrils with a Ki value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Abeta complexes. Pittsburgh Compound B is applicable to Alzheimers disease research[1][2].
Molecular Weight:
256.33
Purity:
98
CAS Number:
[566169-93-5]
Formula:
C14H12N2OS
Target:
Amyloid-beta
Application Notes:
MCE Product type: Reference compound
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