AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM[1].
Molecular Weight:
442.32
Purity:
98.09
CAS Number:
[2247919-28-2]
Formula:
C21H13Cl2N3O2S
Target:
Apoptosis,Aurora Kinase,Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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