Entrectinib-d8, CAS [[2251773-94-9]]

Product Overview

• Article Name: Entrectinib-d8, CAS [[2251773-94-9]]
• Biozol Catalog Number: MCE-HY-12678S1
• Supplier Catalog Number: HY-12678S1
• Alternative Catalog Number: MCE-HY-12678S1-1MG,MCE-HY-12678S1-5MG,MCE-HY-12678S1-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: NMS-E628-d8, RXDX-101-d8

Product Description

Entrectinib-d8 (NMS-E628-d8, RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice[1][2][3][4].

Product Properties

• Molecular Weight: 568.69
• Purity: 99.82
• CAS Number: [2251773-94-9]
• Formula: C31H26D8F2N6O2
• Target: Anaplastic lymphoma kinase (ALK),Autophagy,Isotope-Labeled Compounds,ROS Kinase,Trk Receptor

Application Notes

• Application Notes: Isotope-Labeled Compounds