YHO-13177, a acrylonitrile derivative, is an orally active, potent and specific inhibitor of breast cancer resistance protein (BCRP) and ABCG2 with an IC50 value of 10 nM. YHO-13177 potentiates the cytotoxicity of SN-38 in HCT116 and A549 cells that express BCRP. YHO-13177 combined with Irinotecan (HY-16562) significantly suppresses the tumor growth in an HCT116/BCRP xenograft model[1][2][3].
Molecular Weight:
370.47
Purity:
99.65
CAS Number:
[912287-56-0]
Formula:
C20H22N2O3S
Target:
BCRP
Application Notes:
MCE Product type: Reference compound
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