FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors[1].
Molecular Weight:
510.63
Purity:
99.85
CAS Number:
[1247018-19-4]
Formula:
C26H31FN6O2S
Target:
Farnesyl Transferase
Application Notes:
MCE Product type: Reference compound1
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