The Tubulysin family of secondary metabolites was originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizers and anti-microtubule toxins (anti-microtubule toxins), with effective IC50 concentrations against multidrug-resistant cancer cell lines. In the picomole range. Tubulysins are ideal candidates for incorporation into small active molecule conjugate (SMDC) delivery systems and are commonly used in ADC synthesis as ADC cytotoxins (ADC Cytotoxin)[1].
Molecular Weight:
842.10
Purity:
99.53
CAS Number:
[1943604-24-7]
Formula:
C44H67N5O9S
Target:
ADC Payload,Antibiotic,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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