Tubulysin is a microtubule destabilizer that binds to the beta-tubulin peptide site adjacent to the vinca alkaloid binding site and inhibits tubulin polymerization. Tubulysin induces apoptosis and exhibits antiproliferative activity against a variety of human cancer cells, including multidrug-resistant strains. Tubulysin can be conjugated to antibodies via a disulfide-containing quaternary ammonium linker for ADC synthesis. Tubulysin is applicable to tumor-related research[1][2][3].
Molecular Weight:
842.10
Purity:
99.53
CAS Number:
[1943604-24-7]
Formula:
C44H67N5O9S
Target:
ADC Payload,Antibiotic,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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