SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. SKI-178 is cytotoxic at IC50 concentrations ranging from 1.8 to 0.1 µM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines[1][2].
Molecular Weight:
394.42
Purity:
99.29
CAS Number:
[1259484-97-3]
Formula:
C21H22N4O4
Target:
Apoptosis,SphK
Application Notes:
MCE Product type: Reference compound
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