SLR080811 is a guanidine-based selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 1.3 µM, exhibiting ~10-fold selectivity over SphK1 (Ki = 12 µM). SLR080811 reduces sphingosine 1-phosphate (S1P) levels in vitro, but drives a SphK1-dependent increase in S1P in mice. SLR080811 can be used for cancers and fibrosis research[1].
Molecular Weight:
369.50
CAS Number:
[1449765-65-4]
Formula:
C21H31N5O
Target:
SphK
Application Notes:
MCE Product type: Reference compound
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