MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4,11 cells and 3.4 nM for p53 mutant RS4,11/IRMI-2 cells, respectively. Anticancer activity[1].
Molecular Weight:
774.71
Purity:
98.68
CAS Number:
[2411085-89-5]
Formula:
C41H42Cl2FN5O5
Target:
Apoptosis,Molecular Glues,PROTACs
Application Notes:
MCE Product type: Reference compound
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