DT2216, CAS [[2365172-42-3]]

Product Overview

• Article Name: DT2216, CAS [[2365172-42-3]]
• Biozol Catalog Number: MCE-HY-130604
• Supplier Catalog Number: HY-130604
• Alternative Catalog Number: MCE-HY-130604-5MG,MCE-HY-130604-25MG,MCE-HY-130604-50MG,MCE-HY-130604-10MG,MCE-HY-130604-100MG,MCE-HY-130604-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

DT2216 is a potent and selective BCL-XL (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax-piperazine (HY-44432), a linker, and a VHL E3 ubiquitin ligase (Pink: Navitoclax-piperazine, Blue: VHL ligand, Black: linker)[1].

Product Properties

• Molecular Weight: 1542.36
• Purity: 99.97
• CAS Number: [2365172-42-3]
• Formula: C77H96ClF3N10O10S4
• Target: Apoptosis,Bcl-2 Family,PROTACs

Application Notes

• Application Notes: Reference compound