K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits 70% degradation efficacy in SW1573 cells[1].
Molecular Weight:
697.82
Purity:
98.76
CAS Number:
[2378261-83-5]
Formula:
C35H51N7O8
Target:
Target Protein Ligand-Linker Conjugates
Application Notes:
MCE Product type: Reference compound
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