BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2].
Molecular Weight:
639.14
Purity:
97.18
CAS Number:
[2447066-00-2]
Formula:
C37H35ClN2O6
Target:
Ligands for Target Protein for PROTAC
Application Notes:
MCE Product type: Reference compound1
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