CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity[1][2].
Molecular Weight:
378.30
Purity:
98.97
CAS Number:
[2453324-32-6]
Formula:
C18H21Cl2N5
Target:
Akt,Apoptosis,Autophagy
Application Notes:
Reference compound
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