M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM)[1]. M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity[2].
Molecular Weight:
385.36
Purity:
99.69
CAS Number:
[1464842-09-8]
Formula:
C20H17F2N3O3
Target:
MetAP
Application Notes:
MCE Product type: Reference compound
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