MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC50=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458), Blue, Hyt (HY-W001578))[1].
Molecular Weight:
718.93
Purity:
98.92
CAS Number:
[2225938-17-8]
Formula:
C42H54N8O3
Target:
Apoptosis,Histone Methyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound
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