Apatinib-d8 (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRbeta[2][3][4].
Molecular Weight:
405.52
Purity:
92.56
CAS Number:
[2468771-43-7]
Formula:
C24H15D8N5O
Target:
Autophagy,c-Kit,RET,Src,VEGFR
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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